Zopiclone (Imovane) is indicated for the short-term therapy and symptomatic reduction of insomnia characterised by difficulty in falling asleep, frequent nocturnal awakenings and/or early morning awakenings.

Treatment with zopiclone should often not exceed 7-10 consecutive days. Use for greater than 2-3 consecutive weeks requires full re-evaluation of the patient. Prescriptions for zopiclone ought to be written for short-term use (7-10 days) and it shouldn’t be prescribed in portions exceeding a 1-month supply.

The use of hypnotics must be restricted for insomnia where disturbed sleep results in impaired daytime functioning.

Dosage and administration:

Imovane should solely be taken when you are able to get a full evening’s sleep (7 to 8 hours) before you should be active once more.
The standard adult dose of zopiclone is one pill simply earlier than you go to bed.
This medication ought to be taken in a single consumption and never readministered during the same night time.
If you’re over 65 years of age the dose is half a tablet taken simply before you go to mattress.
If you could have a liver or kidney drawback, the usual really helpful dose is half a pill taken simply before you go to mattress.

Overdosage:

Signs and symptoms:

Overdose by zopiclone pills is normally manifested by various degrees of central nervous system depression starting from drowsiness to coma according to the quantity ingested. In gentle circumstances, symptoms embrace drowsiness, confusion, and lethargy; in additional extreme cases, signs could include ataxia, hypotonia, hypotension, methaemoglobinaemia, respiratory depression, and coma. Overdose shouldn’t be life threatening unless mixed with other CNS depressants, including alcohol. Other danger components, such as the presence of concomitant sickness and the debilitated state of the affected person, might contribute to the severity of signs and really not often can lead to deadly outcome.

In voluntary or accidental cases of zopiclone overdosage involving doses as a lot as 340 mg, the principal effects reported have been prolonged sleep, drowsiness, lethargy and ataxia.

Recommended therapy:

Symptomatic and supportive therapy in enough medical environment is recommended, attention must be paid to respiratory and cardiovascular capabilities. Gastric lavage or activated charcoal is only helpful when carried out soon after ingestion.

Hemodialysis is of no value as a end result of giant volume of distribution of zopiclone. Flumazenil could also be a useful antidote; nonetheless, flumazenil administration might contribute to the appearance of neurological signs (agitation, anxiety, convulsionsand emotional lability). Intravenous fluids must be administered as needed.